Cisplatin chemistry

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August undefined, 2024

WebCisplatin is a chemotherapy medication used to treat a number of cancers. [2] These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. [2] It is given by injection into a vein. [2] WebSep 30, 2024 · Cisplatin resistance in tumor cells is known mainly due to the reduced accumulation of platinum ions by efflux, detoxification by intracellular GSH, and nucleotide excision repair machinery-mediated nuclear DNA repair.

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WebNov 4, 2013 · Platinum compounds represent one of the great success stories of metals in medicine. Following the serendipitous discovery of the anticancer activity of cisplatin by Rosenberg, a large number of cisplatin variants have been prepared and tested for their ability to kill cancer cells and inhibit tumor … the pension people log in

A Metal-Polyphenol-Coordinated Nanomedicine for Synergistic …

WebJan 28, 2024 · In this study, we sought to provide a comprehensive review of the current state of the science highlighting the use of cisplatin in cancer therapy, with a special emphasis on its molecular mechanisms of action, and treatment modalities including the combination therapy with natural products. WebJul 1, 2024 · Cisplatin is one of the best and first metal-based chemotherapeutic drugs (see Fig. 1 for 3D structure of cisplatin) [10], [287]. It is reported that ∼2 billion U.S. dollars of platinum-based anticancer drugs are sold worldwide [6], [7] and nearly about 50% of all patients are treated with cisplatin [8]. WebThe discoverers of cisplatin observed an unexpected cell phenomenon, then they evaluated what they saw and came to an exciting hypothesis that something was changing cell behavior in a way that might be useful medically. But the first proofs must often come through prudent tests on animals as a necessary step on the way to use in humans siang pharmacy online

Cisplatin 6. Transition Metal Chemistry - Chemistry …

WebConspectusSince its discovery in 1965, the inorganic drug cisplatin has become a mainstay of cancer therapies and has inspired many platinum (Pt)-based compounds to solve … Cisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein. Common side effects include bone marrow suppression, hearing problems, incl… the pension officeWebtrans-Platinum(II) diamminedichloride Cl2H6N2Pt+2 CID 441203 - structure, chemical names, physical and chemical properties, classification, patents, literature ... sian gibson on sunday brunch

"WebOct 5, 2014 · Cisplatin has a molecular weight of 301.1 gm/mol, a density of 3.74 g/cm 3, a melting point of 270° C, a log K ow of -2.19 and a water solubility of 2.53 g/L at 25° … " - Cisplatin chemistry

Cisplatin chemistry

Anticancer Drugs (7.7.5) AQA A Level Chemistry Revision Notes …

WebApr 15, 2024 · The treatment was well tolerated only he developed grade 2 mucositis and weight loss associated with cisplatin [ duration of treatment to reactions onset not stated … WebCisplatin: chemistry, distribution and biotransformation Authors D F Long , A J Repta PMID: 7016212 DOI: 10.1002/bdd.2510020102 Abstract A review of the use of cisplatin …

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WebOct 5, 2014 · Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It has been used for treatment of numerous human cancers including bladder, head and neck, lung, ovarian, and testicular cancers. It is effective against various types of cancers, including carcinoma … WebCisplatin, a platinum analogue, is an alkylating agent used in combination with other agents to treat a variety of solid malignancies, including lung cancer, head and neck cancer, …

WebThe high stability of PTCG NPs during circulation stems from their strong metal-polyphenol coordination interactions, and efficient drug release is realized after cellular internalization. The activated cisplatin elevates the intracellular H 2 O 2 level through cascade reactions. WebCisplatin / chemistry Cisplatin / metabolism* Colonic Neoplasms / metabolism* Colonic Neoplasms / pathology Copper / metabolism Copper / pharmacokinetics Copper Transporter 1 Dose-Response Relationship, Drug Homeostasis Humans Platinum / metabolism Platinum / pharmacokinetics Structure-Activity Relationship Substances Cation Transport Proteins

WebOne of the first known coordination compounds was Peyrone’s Chloride (also known as cis-diamminedichloroplatinum (II), or cis-DDP), first reported in 1845. This compound was not fully understood until 1893, when Alfred Werner deduced its structure and described cis-DDP and its trans isomer in a landmark paper. WebApr 8, 2024 · 1 Beijing National Laboratory for Molecular Sciences; CAS Key Laboratory of Analytical Chemistry for Living Biosystems; National Centre for Mass Spectrometry in Beijing, Institute of Chemistry, ... (NH3)(thiazole)] (trans-PtTz) toward HeLa cells to a similar level of cisplatin, contributable to retarding the repair of 1,3-trans-PtTz crosslinked ...

WebIntroduction: Cisplatin has been indicated for several malignancies all over the world for many years. Increasing patient tolerance for high dose of chemotherapeutics and reducing side effects has been granted by drug encapsulated liposomal systems.

WebCisplatin coordinates to DNA mainly through certain nitrogen atoms of the DNA base pairs; these nitrogen atoms (specifically, the N7 atoms of purines) are free to coordinate to cisplatin because they do not form hydrogen bonds with any other … the pension professionals pty ltdWebCisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, … the pension professionals melbourneWebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. … the pension lifetime allowanceWebHypoxia can induce chemoresistance, which is a significant clinical obstacle in cancer therapy. Here, we assessed development of hypoxia-induced chemoresistance (HICR) against free versus polymeric cisplatin micelles in a triple negative breast cancer cell line, MDA-MB-231. We then explored two strategies for the modulation of HICR against … the pension professionals ptyWebIn the modules on control experiments and the role of platinum electrodes (as well as the discovery of cisplatin), we saw that platinum-containing electrolysis products were responsible for causing both elongation of bacterial cells and regression of murine tumors. We now discuss the origin of these electrolysis products. the pension protection act of 2006 ppaWebCisplatin is a tiny little drug molecule that contains a platinum ion in the middle of a flat square with two chloride ions and two ammonia molecules making up the corners. … sian gouldingWebThe antitumor effects of platinum(IV) complexes, considered prodrugs for cisplatin, are believed to be due to biological reduction of Pt(IV) to Pt(II), with the reduction products binding to DNA and other cellular targets. In this work we used pBR322 DNA to capture the products of reduction of oxopl … Pt(IV) complexes as prodrugs for cisplatin the pension protection fund ombudsman