WebBithionol, a bacteriostatic agent that has been widely used as an ingredient in deodorants, shampoos and surgical soaps, has been used for treating infections with Fasciola spp. since the 1960s ( Keiser and Utzinger, 2007b ). Bithionol is only used in countries where triclabendazole is not available. WebFeb 19, 2024 · Bithionol, a halogenated phenol previously used as a first-line agent for the treatment of fascioliasis in the United States, is no longer available. Praziquantel, which is active against most trematodes (flukes), is typically not active against Fasciola parasites. Therefore, the CDC does not recommend praziquantel therapy for fascioliasis.
Bacteriostatic Agent - an overview ScienceDirect Topics
WebSince October, 1961, the authors have had the opportunity to use both drugs (kindly supplied by Tanabe Seiyaku Co., Ltd., Osaka, Japan) in the treatment of their cases. Bithionol was employed in 24 cases and bithionol sulfoxide in 21 cases with a follow-up study for three years after the termination of treatments. WebOct 11, 2024 · Bithionol, a halogenated phenol previously used as first line agent for the treatment of fascioliasis in USA is no longer available. [ 34] Praziquantel, previously used as an alternative drug... sharpening lino cutting tools
Successful treatment of acute fascioliasis with bithionol
WebJun 23, 1990 · The usual dosage has been 30 to 50 mg/kg daily in three divided doses on alternate days for a total of 10 to 15 doses. Lower doses have been used when this regimen is poorly tolerated. Despite its success, most series reporting bithionol therapy of F hepatica report just under 50% long term cure (14,31). An approximate 50% incidence of … WebBithionol has been shown to be a potent inhibitor of soluble adenylyl cyclase (sAC, Adenylate cyclase type 10 ), an intracellular enzyme important in the catalysis of ATP to … WebAug 5, 2024 · Bithionolum. Bithionolum, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the NDA's for bithionol drug products were withdrawn on October 24, 1967 (see the Federal Register of October 31, 1967 (32 FR 15046)). pork crown roast recipe